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TFC 007

Cat. No. 5108 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
化学名： N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TFC 007

TFC 007 is a potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.

技术数据 for TFC 007

分子量 487.55
公式 C27H29N5O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 927878-49-7
PubChem ID 16040067
InChI Key NLSSUSRERAMBTA-UHFFFAOYSA-N
Smiles O=C(C2CCN(C3=CC=C(NC(C4=CN=C(OC5=CC=CC=C5)N=C4)=O)C=C3)CC2)N1CCOCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TFC 007

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.76 100

制备储备液 for TFC 007

以下数据基于产品分子量 487.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.26 mL 20.51 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
10 mM 0.21 mL 1.03 mL 2.05 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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参考文献 for TFC 007

参考文献是支持产品生物活性的出版物。

Nabe et al (2011) Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 95 27 PMID: 21601002

If you know of a relevant reference for TFC 007, please let us know.

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关键词: TFC 007, TFC 007 supplier, TFC007, hematopoietic, prostaglandin, D, synthase, HPGDS, inhibitors, inhibits, antiallergic, anti-inflammatory, Other, Synthases/Synthetases, 5108, Tocris Bioscience

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