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TFM-4AS-1

Cat. No. 3813 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective androgen receptor modulator (SARM)
化学名： (1S,3aS,3bS,5aR,9aR,9bS,11aS)-6,9a,11a-Trimethyl-7-oxo-N-[2-(trifluoromethyl)phenyl]-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TFM-4AS-1

TFM-4AS-1 is a potent selective androgen receptor modulator (SARM) (IC50 = 30 nM). Steroidal compound. Exhibits limited effects on reproductive tissues and sebaceous glands; does not repress AP-1-sensitive MMP-1 reporter. Inhibits 5α-reductase type I and II (IC50 values are 2 and 3 nM respectively).

技术数据 for TFM-4AS-1

分子量 474.56
公式 C27H33F3N2O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 188589-61-9
PubChem ID 10277123
InChI Key YFBLEKKYWFJKBP-JZFZSVFHSA-N
Smiles O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](NC5=C(C(F)(F)F)C=CC=C5)=O)([H])N1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TFM-4AS-1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.75 10
ethanol 4.75 10

制备储备液 for TFM-4AS-1

以下数据基于产品分子量 474.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 21.07 mL 105.36 mL 210.72 mL
0.5 mM 4.21 mL 21.07 mL 42.14 mL
1 mM 2.11 mL 10.54 mL 21.07 mL
5 mM 0.42 mL 2.11 mL 4.21 mL

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参考文献 for TFM-4AS-1

参考文献是支持产品生物活性的出版物。

Schmidt et al (2009) Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 284 36367 PMID: 19846549

If you know of a relevant reference for TFM-4AS-1, please let us know.

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关键词: TFM-4AS-1, TFM-4AS-1 supplier, selective, androgen, receptor, modulator, AR, ligand, SARM, receptors, Androgen, Receptor, Other, Reductase, 3813, Tocris Bioscience

1 篇 TFM-4AS-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TFM-4AS-1 的部分引用包括：

Jennifer J et al (2020) Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition. Toxicol Sci 177 466-475 PMID: 32726424

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