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TH 1020

Cat. No. 6191 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6191 has been discontinued.

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说明： Toll-like receptor (TLR) 5/Flagellin complex antagonist
化学名： 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
纯度： ≥98% (HPLC)
说明书
引用文献
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通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for TH 1020

TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

技术数据 for TH 1020

分子量 453.54
公式 C23H15N7S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1841460-82-9
PubChem ID 124203921
InChI Key CBBXTGWSGPEJEE-UHFFFAOYSA-N
Smiles N1(C(SC2=C3SC4=NC=CC=C4C3=NC=N2)=NN=C1C5=CC=NC=C5)CC6=CC=CC=C6

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TH 1020

参考文献是支持产品生物活性的出版物。

Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID: 26634412

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关键词: TH 1020, TH 1020 supplier, TH1020, Toll, like, receptor, flagellin, complex, TLR5, TNFalpha, TNFa, TNFα, Toll-like, Receptors, 6191, Tocris Bioscience

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Pathways for TH 1020

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.