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TH 10785

Cat. No. 7778 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： OGG1 activator
化学名： N-Cyclohexyl-2-cyclopropyl-4-quinazolinamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TH 10785

TH 10785 is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. It binds in the active site of OGG1 and increases its recruitment to oxidative DNA damage and its repair.

技术数据 for TH 10785

分子量 267.38
公式 C17H21N3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1002801-51-5
PubChem ID 8078523
InChI Key ZQMGQZOHIDOPCQ-UHFFFAOYSA-N
Smiles C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TH 10785

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.74 100
ethanol 26.74 100

制备储备液 for TH 10785

以下数据基于产品分子量 267.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.7 mL 37.4 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for TH 10785

参考文献是支持产品生物活性的出版物。

Michel et al (2022) Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science 376 1471 PMID: 35737787

If you know of a relevant reference for TH 10785, please let us know.

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关键词: TH 10785, TH 10785 supplier, TH10785, OGG1, 8-oxoguanine, DNA, glycosylase, activators, activates, damage, repair, Glycosylases, Enzyme, Substrates, /, Activators, 7778, Tocris Bioscience

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