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TH 1760

Cat. No. 7422 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective NUDT15 hydrolase inhibitor
化学名： 6-[[4-(1H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3H)-benzoxazolone
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TH 1760

TH 1760 is a potent and selective NUDT15 (nudix hydrolase 15) inhibitor (IC50 = 29 nM). Displays selectivity for NUDT15 when assayed at 100 μM against other Nudix enzymes (MTH1, NUDT2, 5, 9, 12, 14, 18, 22) and pyrophosphatases or at 10 μM when assayed with a Eurofins Cerep Safety Screen44 panel. In vitro, TH 1760 treatment sensitizes cancer cell lines (NB4 and HL-60) to thiopurine.

技术数据 for TH 1760

分子量 426.45
公式 C20H18N4O5S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2567914-01-4
PubChem ID 146048072
InChI Key HNCVDRFFJZJQRW-UHFFFAOYSA-N
Smiles O=C(C1=CC=C2NC=CC2=C1)N3CCN(S(=O)(C4=CC=C5NC(OC5=C4)=O)=O)CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TH 1760

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.2 10 温和加热

制备储备液 for TH 1760

以下数据基于产品分子量 426.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 23.45 mL 117.25 mL 234.49 mL
0.5 mM 4.69 mL 23.45 mL 46.9 mL
1 mM 2.34 mL 11.72 mL 23.45 mL
5 mM 0.47 mL 2.34 mL 4.69 mL

Molarity Calculator

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Dilution Calculator

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参考文献 for TH 1760

参考文献是支持产品生物活性的出版物。

Zhang et al (2020) Development of a chemical probe against NUDT15. Nat.Chem.Biol. 16 1120 PMID: 32690945

If you know of a relevant reference for TH 1760, please let us know.

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关键词: TH 1760, TH 1760 supplier, TH1760, nudix, hydrolase, 15, inhibitors, inhibits, potent, selective, NUDT15, cancer, Other, Hydrolases, 7422, Tocris Bioscience

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