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TH 5487

Cat. No. 6749 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
化学名： 4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TH 5487

TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro. Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo.

许可信息

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

技术数据 for TH 5487

分子量 541.18
公式 C19H18BrIN4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2304947-71-3
PubChem ID 137321164
InChI Key FZLKVWWPFOLPKF-UHFFFAOYSA-N
Smiles O=C(NC1=CC=C(I)C=C1)N(CC2)CCC2N(C3=CC=CC(Br)=C3N4)C4=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TH 5487

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 54.12 100

制备储备液 for TH 5487

以下数据基于产品分子量 541.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.24 mL 18.48 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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参考文献 for TH 5487

参考文献是支持产品生物活性的出版物。

Visnes et al (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 362 834 PMID: 30442810

If you know of a relevant reference for TH 5487, please let us know.

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关键词: TH 5487, TH 5487 supplier, TH5487, OGG1, inhibitors, inhibits, selective, 8-oxoguanine, DNA, glycosylase, 1, repair, enzymes, anti-inflammatory, Glycosylases, 6749, Tocris Bioscience

2 篇 TH 5487 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TH 5487 的部分引用包括：

Eric L et al (2022) Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons. Int J Mol Sci 23 PMID: 35163831

Janice et al (2022) Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSα facilitates processing of oxidative DNA damage in human cells. J Biol Chem 298 102102 PMID: 35667440

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