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Submit ReviewTH 5487
说明： Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
化学名： 4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for TH 5487
TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro. Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo.
许可信息
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.
技术数据 for TH 5487
| 分子量 | 541.18 |
| 公式 | C19H18BrIN4O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2304947-71-3 |
| PubChem ID | 137321164 |
| InChI Key | FZLKVWWPFOLPKF-UHFFFAOYSA-N |
| Smiles | O=C(NC1=CC=C(I)C=C1)N(CC2)CCC2N(C3=CC=CC(Br)=C3N4)C4=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TH 5487
参考文献 for TH 5487
参考文献是支持产品生物活性的出版物。
Visnes et al (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 362 834 PMID: 30442810
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关键词: TH 5487, TH 5487 supplier, TH5487, OGG1, inhibitors, inhibits, selective, 8-oxoguanine, DNA, glycosylase, 1, repair, enzymes, anti-inflammatory, Glycosylases, 6749, Tocris Bioscience
2 篇 TH 5487 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TH 5487 的部分引用包括：
Eric L et al (2022) Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons. Int J Mol Sci 23 PMID: 35163831
Janice et al (2022) Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSα facilitates processing of oxidative DNA damage in human cells. J Biol Chem 298 102102 PMID: 35667440
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