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TH 588

Cat. No. 5334 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5334 has been discontinued.

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说明： Potent MTH1 inhibitor
化学名： N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 说明书 参考文献

生物活性 for TH 588

TH 588 is a potent MTH1 inhibitor (IC50 = 5 nM). Induces oxidative DNA damage and reduces survival in cancer cells. Inhibits growth of breast and colorectal cancer xenografts in mice.

许可信息

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

技术数据 for TH 588

分子量 295.17
公式 C13H12Cl2N4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1609960-31-7
PubChem ID 73389731
InChI Key PNMYJIOQIAEYQL-UHFFFAOYSA-N
Smiles NC1=NC(C2=C(Cl)C(Cl)=CC=C2)=CC(NC3CC3)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TH 588

参考文献是支持产品生物活性的出版物。

Gad et al (2014) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508 215 PMID: 24695224

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关键词: TH 588, TH 588 supplier, TH588, MTH1, MutT, homolog-1, inhibitors, inhibits, potent, NUDT1, (MTH1), 5334, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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