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TH 9619 disodium salt

Cat. No. 7719 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： MTHFD2 inhibitor
化学名： Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TH 9619 disodium salt

TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AML) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AML.

许可信息

Sold under license from Thomas Helleday's Foundation for Medical Research and One-Carbon Therapeutics

技术数据 for TH 9619 disodium salt

分子量 495.33
公式 C17H16FN7Na2O7
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key AKIUEXPYEGJOLL-WWPIYYJJSA-L
Smiles NC1=NC(C(CC(NC2=CN=C(C(F)=C2)C(N[C@H](C(O[Na])=O)CCC(O[Na])=O)=O)=O)=C(N1)N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TH 9619 disodium salt

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 9.91 20 温和加热

制备储备液 for TH 9619 disodium salt

以下数据基于产品分子量 495.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 10.09 mL 50.47 mL 100.94 mL
1 mM 2.02 mL 10.09 mL 20.19 mL
2 mM 1.01 mL 5.05 mL 10.09 mL
10 mM 0.2 mL 1.01 mL 2.02 mL

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产品说明书 for TH 9619 disodium salt

分析证书/产品说明书
化学品安全技术说明书

参考文献 for TH 9619 disodium salt

参考文献是支持产品生物活性的出版物。

Bonagas et al (2022) Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat.Cancer 3 156 PMID: 35228749

If you know of a relevant reference for TH 9619 disodium salt, please let us know.

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关键词: TH 9619 disodium salt, TH 9619 disodium salt supplier, TH9619, inhibitors, inhibits, potent, selective, acute, myeloid, leukemia, AML, cancer, , in, vivo, Other, Dehydrogenases, 7719, Tocris Bioscience

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