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Thalidomide, 5'-fluoro

Cat. No. 7456 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
化学名： 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione
纯度： ≥95%
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生物活性 技术数据 说明书 参考文献

生物活性 for Thalidomide, 5'-fluoro

Thalidomide 5'- fluoro is a derivative of Thalidomide (Cat. No. 0652), commonly used as a precursor to PROTAC® Degraders that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a fluoro functional handle at a position known not to significantly affect binding to cereblon, ready for conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines for Thalidomide, 5'-fluoro

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for Thalidomide, 5'-fluoro

分子量 276.22
公式 C13H9FN2O4
储存 Store at +4°C
纯度 ≥95%
CAS Number 835616-61-0
PubChem ID 70876201
InChI Key MPQLCQKBYRSPNA-UHFFFAOYSA-N
Smiles FC1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Thalidomide, 5'-fluoro

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Thalidomide, 5'-fluoro

参考文献是支持产品生物活性的出版物。

Burslem et al (2018) Efficient synthesis of immunomodulatory drug analogues enables exploration of structure-degradation relationships. Chem.Med.Chem. 13 1508 PMID: 29870139

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia