THDOC

Cat. No. 6334 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Positive modulator of GABA_A receptors; endogenous neurosteroid

化学名： (3α,5α)-3,21-Dihydroxypregnan-20-one

纯度： ≥95% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for THDOC

THDOC is a positive modulator of GABA_A receptors. Potentiates neuronal response to low concentrations of GABA at α4β1δ GABA_A receptors in vitro. Endogenous neurosteroid.

技术数据 for THDOC

分子量	334.49
公式	C₂₁H₃₄O₃
储存	Store at RT
纯度	≥95% (HPLC)
CAS Number	567-02-2
PubChem ID	91475
InChI Key	CYKYBWRSLLXBOW-SIDISFDHSA-N
Smiles	[H][C@@]12CC[C@@H]([C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](CC[C@]34C)O)[H])[H])[H])C)C(CO)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for THDOC

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	33.45	100
	ethanol	33.45	100

制备储备液 for THDOC

以下数据基于产品分子量 334.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.99 mL	14.95 mL	29.9 mL
5 mM	0.6 mL	2.99 mL	5.98 mL
10 mM	0.3 mL	1.49 mL	2.99 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for THDOC

分析证书/产品说明书

化学品安全技术说明书

参考文献 for THDOC

参考文献是支持产品生物活性的出版物。

Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABA_A receptors expressed in Xenopus oocytes. BMC.Neurosci. 16 PMID: 25887256

Adams et al (2015) Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABA_A receptors. Neuropharmacology. 88 63 PMID: 25278033

If you know of a relevant reference for THDOC, please let us know.

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关键词: THDOC, THDOC supplier, GABAA, receptor, modulators, modulates, positive, neurosteroid, endogenous, Receptors, 6334, Tocris Bioscience

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