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说明： Glutamate receptor ligand
化学名： N-Ethyl-L-glutamine
生物活性 for Theanine
Amino acid analog of glutamine and component of green tea. Shown to bind to AMPA, Kainate, NMDA and group I mGlu receptors. Displays neuroprotective effects in vivo. Promotes self-renewal of human embryonic stem cells (hESC).
技术数据 for Theanine
| 分子量 | 174.2 |
| 公式 | C7H14N2O3 |
| 储存 | Store at RT |
| CAS Number | 3081-61-6 |
| PubChem ID | 439378 |
| InChI Key | DATAGRPVKZEWHA-YFKPBYRVSA-N |
| Smiles | CCNC(CC[C@H](N)C(O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Theanine
参考文献 for Theanine
参考文献是支持产品生物活性的出版物。
Kakuda et al (2002) Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Biosci.Biotechnol.Biochem. 66 2683 PMID: 12596867
Egashira et al (2008) Theanine prevents memory impairment induced by repeated cerebral ischemia in rats. Phytother.Res. 22 65 PMID: 17705146
Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell. 2 602 PMID: 18522853
Nagasawa et al (2004) Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochem.Biophys.Res.Comm. 320 116
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关键词: Theanine, Theanine supplier, glutamate, glutamine, analogue, receptors, metabotropic, mGlu, NMDA, Kainate, AMPA, ligands, hESC, human, embryonic, stem, cells, Miscellaneous, Glutamate, Stem, Cell, Proliferation, 3847, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.