Thiamet G

Cat. No. 4390 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent O-GlcNAcase inhibitor

化学名： (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Thiamet G

Thiamet G is a potent, selective inhibitor of O-GlcNAcase (K_i = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

技术数据 for Thiamet G

分子量	248.3
公式	C₉H₁₆N₂O₄S
储存	Store at -20°C
CAS Number	1009816-48-1
PubChem ID	24808478
InChI Key	PPAIMZHKIXDJRN-FMDGEEDCSA-N
Smiles	CCNC2=N[C@]1([H])[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]([H])1S2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Thiamet G

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	12.41	50

制备储备液 for Thiamet G

以下数据基于产品分子量 248.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	8.05 mL	40.27 mL	80.55 mL
2.5 mM	1.61 mL	8.05 mL	16.11 mL
5 mM	0.81 mL	4.03 mL	8.05 mL
25 mM	0.16 mL	0.81 mL	1.61 mL

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产品说明书 for Thiamet G

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Thiamet G

参考文献是支持产品生物活性的出版物。

Yuzwa et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 4 483 PMID: 18587388

Zhu et al (2018) Pharmacological inhibition of O-GlcNAcase enhances autophagy in brain through an mTOR-independent pathway ACS Chem.Neurosci. 9 1366 PMID: 29460617

If you know of a relevant reference for Thiamet G, please let us know.

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关键词: Thiamet G, Thiamet G supplier, glycosidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, O-GlcNAcase, ThiametG, Other, Hydrolases, 4390, Tocris Bioscience