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Submit ReviewTianeptine sodium salt
说明： Selective facilitator of 5-HT uptake; antidepressant
化学名： 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid sodium salt
纯度： ≥99% (HPLC)
生物活性 for Tianeptine sodium salt
Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.
技术数据 for Tianeptine sodium salt
| 分子量 | 458.93 |
| 公式 | C21H24ClN2NaO4S |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 30123-17-2 |
| PubChem ID | 23663953 |
| InChI Key | ZLBSUOGMZDXYKE-UHFFFAOYSA-M |
| Smiles | [Na+].CN1C2=CC=CC=C2C(NCCCCCCC([O-])=O)C2=CC=C(Cl)C=C2S1(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Tianeptine sodium salt
参考文献 for Tianeptine sodium salt
参考文献是支持产品生物活性的出版物。
Kato and Weitsch (1988) Neurochemical profile of tianeptine, a new antidepressant drug. Clin.Neuropharmacol. 11 S43 PMID: 3052825
Uzbay et al (1999) Analgesic effect of tianeptine in mice. Life Sci. 64 1313 PMID: 10227587
Plaisant et al (2003) Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology 44 801 PMID: 12681378
Mennini et al (1987) Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmied.Arch.Pharmacol. 336 478
关键词: Tianeptine sodium salt, Tianeptine sodium salt supplier, Selective, facilitator, 5-HT, reuptake, antidepressant, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 1972, Tocris Bioscience
2 篇 Tianeptine sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tianeptine sodium salt 的部分引用包括：
Makani et al (2013) Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells. Mol Cell Endocrinol 381 175 PMID: 23933152
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Nature 40 766 PMID: 25249058
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.