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Submit ReviewTiotidine
说明： Potent and selective H2 antagonist
别名： ICI 125,211
纯度： ≥98% (HPLC)
生物活性 for Tiotidine
Tiotidine is a potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.
许可信息
Sold with the permission of AstraZeneca UK Ltd.
技术数据 for Tiotidine
| 分子量 | 312.41 |
| 公式 | C10H16N8S2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 69014-14-8 |
| PubChem ID | 50287 |
| InChI Key | YDDXVAXDYKBWDX-UHFFFAOYSA-N |
| Smiles | CN\C(NCCSCC1=CSC(\N=C(/N)N)=N1)=N/C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Tiotidine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 10 | ||
| DMSO | 100 |
制备储备液 for Tiotidine
以下数据基于产品分子量 312.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.2 mL | 16 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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产品说明书 for Tiotidine
参考文献 for Tiotidine
参考文献是支持产品生物活性的出版物。
Hill (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693
Trzeciakowski and Levi (1980) The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist. J.Pharmacol.Exp.Ther. 214 629 PMID: 6105207
Yellin et al (1979) ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors. Life Sci. 25 2001 PMID: 43449
If you know of a relevant reference for Tiotidine, please let us know.
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关键词: Tiotidine, Tiotidine supplier, Potent, selective, H2, antagonists, Receptors, Histamine, histaminergic, AstraZeneca, ICI125211, ICI, 125,211, 0826, Tocris Bioscience
5 篇 Tiotidine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tiotidine 的部分引用包括：
Chigaev et al (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem 286 20375 PMID: 21515675
Alonso et al (2015) Physiological implications of biased signaling at histamine H2 receptors. Exp Ther Med 6 45 PMID: 25805997
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809
Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Front Pharmacol 152 891 PMID: 17891168
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.