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TL 13-112

Cat. No. 6745 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective ALK Degrader (PROTAC®)
化学名： N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TL 13-112

TL 13-112 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302) conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h.

Negative control TL 13-110 (Cat. No. 6746), and ALK antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4210.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

许可信息

Sold under license from Dana-Farber Cancer Institute

技术数据 for TL 13-112

分子量 1002.57
公式 C49H60ClN9O10S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2229037-19-6
Smiles CC(OC1=CC(C2CCN(CC2)CCOCCOCCNC(CNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)=C(C=C1NC6=NC=C(C(NC7=CC=CC=C7S(=O)(C(C)C)=O)=N6)Cl)C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TL 13-112

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.13 50

制备储备液 for TL 13-112

以下数据基于产品分子量 1002.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 1.99 mL 9.97 mL 19.95 mL
2.5 mM 0.4 mL 1.99 mL 3.99 mL
5 mM 0.2 mL 1 mL 1.99 mL
25 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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Reconstitution Calculator

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产品说明书 for TL 13-112

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TL 13-112

参考文献是支持产品生物活性的出版物。

Powell et al (2019) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID: 29660984

If you know of a relevant reference for TL 13-112, please let us know.

按标靶查看相关产品

关键词: TL 13-112, TL 13-112 supplier, TL13-112, protac, protacs, targeted, protein, degradation, TPD, active, degraders, degrades, ALK, Anaplastic, Lymphoma, Kinase, degronimides, Degraders, 6745, Tocris Bioscience

3 篇 TL 13-112 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TL 13-112 的部分引用包括：

Ma et al (2023) Engineered PROTAC-CID systems for mammalian inducible gene regulation. J Am Chem Soc 145 1593 PMID: 36626587

Martina et al (2023) Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma. Front Oncol 12 1085672 PMID: 36698412

Cinzia et al (2022) Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma. Blood 139 717-731 PMID: 34657149

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia