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Submit ReviewTM N1324
说明： Potent and selective GPR39 agonist; orally bioavailable
化学名： 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one
纯度： ≥98% (HPLC)
生物活性 for TM N1324
TM N1324 is a potent and selective GPR39 agonist (IC50 values are 280 and 9 nM in the absence and presence of Zn2+, respectively). Exhibits no significant activity against a panel of 165 other GPCRs. Inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Cell permeable and orally bioavailable.
技术数据 for TM N1324
| 分子量 | 397.79 |
| 公式 | C18H13ClFN7O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1144477-35-9 |
| PubChem ID | 42654322 |
| InChI Key | AAKZKVKEKKTMRJ-UHFFFAOYSA-N |
| Smiles | CC1=NN(C2=C3NC=NC3=NC=N2)C4=C1C(C5=C(C=C(C=C5)F)Cl)CC(N4)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TM N1324
参考文献 for TM N1324
参考文献是支持产品生物活性的出版物。
Frimurer et al (2017) Model-based discovery of synthetic agonists for the Zn2+-sensing G-protein-coupled receptor 39 (GPR39) reveals novel biological functions. J.Med.Chem. 60 886 PMID: 28045522
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关键词: TM N1324, TM N1324 supplier, TMN1324, gpr39, agonists, agonism, potent, selective, orally, bioavailable, cell, permeable, zn2+, zinc, Orphan, 7-TM, Receptors, 6325, Tocris Bioscience
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