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Submit ReviewTMN 355
说明： Cyclophilin A inhibitor
化学名： 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
纯度： ≥98% (HPLC)
生物活性 for TMN 355
TMN 355 is a potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).
技术数据 for TMN 355
| 分子量 | 380.8 |
| 公式 | C21H14ClFN2O2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1186372-20-2 |
| PubChem ID | 44249042 |
| InChI Key | SFNLLCUAISZNRV-UHFFFAOYSA-N |
| Smiles | ClC1=C(C(NC(NC2C(C=CC=C4)=C4C3=C2C=CC=C3)=O)=O)C(F)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TMN 355
参考文献 for TMN 355
参考文献是支持产品生物活性的出版物。
Ni et al (2009) Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 52 5295 PMID: 19691347
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关键词: TMN 355, TMN 355 supplier, TMN355, cyclophilin, a, cypA, immunosuppressants, immunophilins, ppiase, inhibitors, inhibits, Other, Isomerases, 4152, Tocris Bioscience
2 篇 TMN 355 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TMN 355 的部分引用包括：
Ke et al (2020) Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner. Front Cell Dev Biol 8 784 PMID: 32903542
Ahmed-Belkacem et al (2016) Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nature Communications 7 12777 PMID: 27652979
TMN 355 的评论
平均评分: 5 (Based on 1 Review.)
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We used TMN 355 to inhibit response for our study.
By
Anonymous on 02/20/2019
种属： Human
Cyclophilin A is secreted from these monocytes, endothelial cells and vascular smooth muscle cells in response to inflammatory stimuli such as hyperglycemia, hypoxia, infection and oxidative stress.We used TMN 355 to inhibit such response for our study.
