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说明： Cytochrome P450 1B1 inhibitor
别名： (E)-2,3',4,5'-tetramethoxystilbene
化学名： 1-[2,(3,5-Dimethoxyphenyl)ethenyl]-2,4-dimethoxybenzene
纯度： ≥98% (HPLC)
生物活性 for TMS
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro.
技术数据 for TMS
| 分子量 | 300.35 |
| 公式 | C18H20O4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 24144-92-1 |
| PubChem ID | 5354004 |
| InChI Key | JDBCWSHYEQUBLW-AATRIKPKSA-N |
| Smiles | COC1=CC(OC)=C(\C=C\C2=CC(OC)=CC(OC)=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TMS
参考文献 for TMS
参考文献是支持产品生物活性的出版物。
Chun et al (2001) A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Cancer Res. 61 8164 PMID: 11719446
Kim et al (2002) Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J.Med.Chem. 45 160 PMID: 11754588
Nam et al (2001) Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Arch.Pharm.Res. 24 441 PMID: 11693548
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关键词: TMS, TMS supplier, Cytochrome, P450, 1B1, inhibitors, inhibits, CYP, (E)-2,3',4,5'-tetramethoxystilbene, 1509, Tocris Bioscience
1 篇 TMS 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TMS 的部分引用包括：
Hood et al (2016) Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension. Hypertension 68 796 PMID: 27402919
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