TNP-ATP triethylammonium salt

Cat. No. 2464 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective P2X antagonist

化学名： 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt

纯度： ≥95% (HPLC)

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TNP-ATP triethylammonium salt

TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X₁, P2X₃ and heteromeric P2X_2/3 receptors with IC₅₀ values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X₂, P2X₄ and P2X₇.

技术数据 for TNP-ATP triethylammonium salt

分子量	1123.04
公式	C₁₆H₁₃N₈O₁₉P₃.4C₆H₁₆N
储存	Store at -20°C
纯度	≥95% (HPLC)
PubChem ID	75358143
InChI Key	XTSNRUFLZVGKOU-NRBYJGOSSA-O
Smiles	NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])(O)=O)([O-])=O)([O-])=O)[C@]4([H])[C@]([H])3OC(C([N+]([O-])=O)=C/C(C=C5[N+]([O-])=O)=[N+]([O-])/[O-])5O4)C=N2)=NC=N1.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC.CC[N+](CC)([H])CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TNP-ATP triethylammonium salt

溶解性	Soluble in water (supplied pre-dissolved at a concentration of 10mM)

产品说明书 for TNP-ATP triethylammonium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TNP-ATP triethylammonium salt

参考文献是支持产品生物活性的出版物。

Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X₁, P2X₃ and heteromeric P2X_2/3 receptors. Mol.Pharmacol. 53 969 PMID: 9614197

Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463 PMID: 9723959

Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509.2 411 PMID: 9575290

Burgard et al (2000) Competitive antagonism of recombinant P2X_(2/3)receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). Mol.Pharmacol. 58 1502 PMID: 11093790

Spelta et al (2002) Kinetics of antagonist actions at rat P2X_2/3 heteromeric receptors. Br.J.Pharmacol. 135 1524 PMID: 11906966

If you know of a relevant reference for TNP-ATP triethylammonium salt, please let us know.

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Purinergic (P2X) Receptors

关键词: TNP-ATP triethylammonium salt, TNP-ATP triethylammonium salt supplier, Potent, selective, P2X, antagonists, Receptors, Purinergic, purinoceptors, 61368-63-6, 120360-48-7, 2464, Tocris Bioscience

5 篇 TNP-ATP triethylammonium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TNP-ATP triethylammonium salt 的部分引用包括：

Ghalali et al (2014) Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells. J Biol Chem 289 11601 PMID: 24599953

Mohammed et al (2017) Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep 7 45221 PMID: 28338073

McEwan et al (2021) Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation Life Sci 283 119850 PMID: 34314735

Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787 PMID: 22753954

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Naunyn Schmiedebergs Arch Pharmacol 305 F396 PMID: 23720349

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