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Submit ReviewTomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.
分子量 | 291.82 |
公式 | C17H21NO.HCl |
储存 | Store at RT |
纯度 | ≥99% (HPLC) |
CAS Number | 82248-59-7 |
PubChem ID | 54840 |
InChI Key | LUCXVPAZUDVVBT-UNTBIKODSA-N |
Smiles | Cl[H].CNCC[C@@H](OC1=C(C)C=CC=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 14.59 | 50 温和加热 |
以下数据基于产品分子量 291.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.5 mM | 6.85 mL | 34.27 mL | 68.54 mL |
2.5 mM | 1.37 mL | 6.85 mL | 13.71 mL |
5 mM | 0.69 mL | 3.43 mL | 6.85 mL |
25 mM | 0.14 mL | 0.69 mL | 1.37 mL |
参考文献是支持产品生物活性的出版物。
Wong et al (1982) A new inhibitor of NE uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 222 61 PMID: 6123593
Bymaster et al (2002) Atomoxetine increases extracellular levels of NE and DA in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27 699 PMID: 12431845
If you know of a relevant reference for Tomoxetine hydrochloride, please let us know.
关键词: Tomoxetine hydrochloride, Tomoxetine hydrochloride supplier, Potent, selective, noradrenaline, noradrenalin, reuptake, inhibitors, inhibits, Transporters, adrenaline, adrenalin, NET, Adrenergic, Monoamine, Neurotransmitter, LY139603, Atomoxetine, LY, 139603, 2011, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Tomoxetine hydrochloride 的部分引用包括:
Kobayashi et al (2010) Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine. Neuropsychopharmacology 35 1560 PMID: 20393461
Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. J Neurosci 352 53 PMID: 25332454
Achterberg et al (2015) Methylphenidate and atomox. inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats. Psychopharmacology (Berl) 35 161 PMID: 25568111
Finnema et al (2015) Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain. Toxins (Basel) 18 PMID: 25522417
Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. Int J Neuropsychopharmacol 231 2671 PMID: 24481568
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diluted into saline solution to be injected into animals for observation of behavioral effects