Tomoxetine hydrochloride

Pricing Availability   Qty
说明: Potent and selective noradrenalin re-uptake inhibitor
别名: Atomoxetine,LY 139603
化学名: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
纯度: ≥99% (HPLC)
说明书
引用文献 (5)
评论 (1)

生物活性 for Tomoxetine hydrochloride

Tomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.

技术数据 for Tomoxetine hydrochloride

分子量 291.82
公式 C17H21NO.HCl
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 82248-59-7
PubChem ID 54840
InChI Key LUCXVPAZUDVVBT-UNTBIKODSA-N
Smiles Cl[H].CNCC[C@@H](OC1=C(C)C=CC=C1)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tomoxetine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 14.59 50 温和加热

制备储备液 for Tomoxetine hydrochloride

以下数据基于产品分子量 291.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.85 mL 34.27 mL 68.54 mL
2.5 mM 1.37 mL 6.85 mL 13.71 mL
5 mM 0.69 mL 3.43 mL 6.85 mL
25 mM 0.14 mL 0.69 mL 1.37 mL

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产品说明书 for Tomoxetine hydrochloride

分析证书/产品说明书
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参考文献 for Tomoxetine hydrochloride

参考文献是支持产品生物活性的出版物。

Wong et al (1982) A new inhibitor of NE uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 222 61 PMID: 6123593

Bymaster et al (2002) Atomoxetine increases extracellular levels of NE and DA in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27 699 PMID: 12431845


If you know of a relevant reference for Tomoxetine hydrochloride, please let us know.

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查看全部 Adrenergic Transporter Inhibitors

关键词: Tomoxetine hydrochloride, Tomoxetine hydrochloride supplier, Potent, selective, noradrenaline, noradrenalin, reuptake, inhibitors, inhibits, Transporters, adrenaline, adrenalin, NET, Adrenergic, Monoamine, Neurotransmitter, LY139603, Atomoxetine, LY, 139603, 2011, Tocris Bioscience

5 篇 Tomoxetine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tomoxetine hydrochloride 的部分引用包括:

Kobayashi et al (2010) Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine. Neuropsychopharmacology 35 1560 PMID: 20393461

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. J Neurosci 352 53 PMID: 25332454

Achterberg et al (2015) Methylphenidate and atomox. inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats. Psychopharmacology (Berl) 35 161 PMID: 25568111

Finnema et al (2015) Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain. Toxins (Basel) 18 PMID: 25522417

Parker et al (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. Int J Neuropsychopharmacol 231 2671 PMID: 24481568


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Tomoxetine hydrochloride 的评论

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Arrived next day, quality.
By Shannon Ballard on 07/24/2020
分析类型: In Vivo
种属: Rat

diluted into saline solution to be injected into animals for observation of behavioral effects