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Submit ReviewTopotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.
分子量 | 457.91 |
公式 | C23H23N3O5.HCl |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 119413-54-6 |
PubChem ID | 60699 |
InChI Key | DGHHQBMTXTWTJV-BQAIUKQQSA-N |
Smiles | OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2)C2=C1CN(C)C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 45.79 | 100 | |
DMSO | 45.79 | 100 |
以下数据基于产品分子量 457.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.18 mL | 10.92 mL | 21.84 mL |
5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
参考文献是支持产品生物活性的出版物。
Uckun et al (1995) In vitro and in vivo activity of topo. against human B-lineage acute lymphoblastic leukemia cells. Blood 85 2817 PMID: 7742543
Sottile et al (2012) A chemical screen identifies the chemotherapeutic drug topo. as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma. Oncotarget. 3 535 PMID: 22619121
Schellens et al (1996) Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor. Br.J.Cancer 73 1268 PMID: 8630291
If you know of a relevant reference for Topotecan hydrochloride, please let us know.
关键词: Topotecan hydrochloride, Topotecan hydrochloride supplier, Topotecan, HCl, DNA, topoisomerase, inhibitors, chemotherapeutics, Mycn, B-myb, inhibits, supplier, antineoplastics, orally, available, U4, RNA, splicing, SK&F, 104864-A, Topoisomerase, DNA,, and, Protein, Synthesis, 4562, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Topotecan hydrochloride 的部分引用包括:
Florea et al (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget 8 22876 PMID: 28206967
Michael G et al (2021) Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs. Cancer Res 81 400-413 PMID: 33172929
Balmus et al (2019) ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nat Commun 10 87 PMID: 30622252
Martin et al (2017) Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery. Cell Chem Biol 24 624-634.e3 PMID: 28434878
Pearson et al (2016) Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Int J Mol Med 7 11173 PMID: 27029645
Jen Q et al (2022) Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma. Cancers (Basel) 14 PMID: 35326650
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