主页 / 药理学 / Enzymes / Hydrolases / Other Hydrolases / Other Hydrolase Inhibitors / TP-040

TP-040

Cat. No. 7771 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective O-GlcNAcase (OGA) inhibitor
化学名： N-[(1-Methyl-1H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TP-040

TP-040 is a potent and selective O-GlcNAcase (OGA) inhibitor (IC50 = 46 nM). It increases the level of O-GlcNAcylated protein in human neuroblastoma SH-SY5Y cells (EC50 = 450 nM). It is suitable for in vivo studies and exhibits brain permeability.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP-040 probe summary on the SGC website.

技术数据 for TP-040

分子量 286.38
公式 C15H22N6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2757254-99-0
PubChem ID 162640825
InChI Key PWKAYICUBVNJAZ-UHFFFAOYSA-N
Smiles CN1C=NC(CNC2=NC=CC(N3CCC(CC3)C)=N2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TP-040

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 28.64 100
DMSO 28.64 100

制备储备液 for TP-040

以下数据基于产品分子量 286.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.92 mL
5 mM 0.7 mL 3.49 mL 6.98 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for TP-040

参考文献是支持产品生物活性的出版物。

Tawada et al (2021) Discovery of a novel and brain-penetrant O-GlcNAcase inhibitor via virtual screening, structure-based analysis, and rational lead optimization. J.Med.Chem. 64 1103 PMID: 33404239

If you know of a relevant reference for TP-040, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Other Hydrolase Inhibitors

关键词: TP-040, TP-040 supplier, potent, selective, O-GlcNAcase, inhibitor, inhibits, OGA, increase, O-GlcNAcylation, brain, permeable, Other, Hydrolases, 7771, Tocris Bioscience

篇 TP-040 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 TP-040 的引用文献。 您是否知道使用了 Tocris TP-040 的优秀论文？ 请告知我们.

TP-040 的评论

目前没有该产品的评论。 Be the first to review TP-040 and earn rewards!

Have you used TP-040?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review