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Submit ReviewTracazolate hydrochloride
说明： Allosteric modulator of GABAA receptors
别名： ICI 136753
化学名： 4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylate hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Tracazolate hydrochloride
Tracazolate hydrochloride is a GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.
技术数据 for Tracazolate hydrochloride
| 分子量 | 340.85 |
| 公式 | C16H24N4O2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1135210-68-2 |
| PubChem ID | 24871267 |
| InChI Key | TUIXDPUEMQXVHO-UHFFFAOYSA-N |
| Smiles | Cl.CCCCNC1=C2C=NN(CC)C2=NC(C)=C1C(=O)OCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Tracazolate hydrochloride
参考文献 for Tracazolate hydrochloride
参考文献是支持产品生物活性的出版物。
Meiners and Salama (1982) Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 78 315 PMID: 6121710
Patel and Malick (1982) Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 78 323 PMID: 6121711
Thompson et al (2002) Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors. Mol.Pharmacol. 61 861 PMID: 11901225
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关键词: Tracazolate hydrochloride, Tracazolate hydrochloride supplier, Subtype-selective, GABAA, allosteric, modulators, Receptors, ICI136753, ICI, 136753, 1558, Tocris Bioscience
1 篇 Tracazolate hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tracazolate hydrochloride 的部分引用包括：
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Neurosci 34 10219 PMID: 25080584
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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