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Tracazolate hydrochloride

Cat. No. 1558 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Allosteric modulator of GABAA receptors
别名： ICI 136753
化学名： 4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylate hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Tracazolate hydrochloride

Tracazolate hydrochloride is a GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.

技术数据 for Tracazolate hydrochloride

分子量 340.85
公式 C16H24N4O2.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 1135210-68-2
PubChem ID 24871267
InChI Key TUIXDPUEMQXVHO-UHFFFAOYSA-N
Smiles Cl.CCCCNC1=C2C=NN(CC)C2=NC(C)=C1C(=O)OCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tracazolate hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 34.09 100

制备储备液 for Tracazolate hydrochloride

以下数据基于产品分子量 340.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.67 mL 29.34 mL
5 mM 0.59 mL 2.93 mL 5.87 mL
10 mM 0.29 mL 1.47 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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产品说明书 for Tracazolate hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Tracazolate hydrochloride

参考文献是支持产品生物活性的出版物。

Meiners and Salama (1982) Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 78 315 PMID: 6121710

Patel and Malick (1982) Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 78 323 PMID: 6121711

Thompson et al (2002) Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors. Mol.Pharmacol. 61 861 PMID: 11901225

If you know of a relevant reference for Tracazolate hydrochloride, please let us know.

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关键词: Tracazolate hydrochloride, Tracazolate hydrochloride supplier, Subtype-selective, GABAA, allosteric, modulators, Receptors, ICI136753, ICI, 136753, 1558, Tocris Bioscience

1 篇 Tracazolate hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tracazolate hydrochloride 的部分引用包括：

Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Neurosci 34 10219 PMID: 25080584

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