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tri-GalNAc biotin

Cat. No. 7635 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Biotinylated ASGPR ligand for LYTAC research and development
纯度： ≥90% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for tri-GalNAc biotin

Tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).

技术数据 for tri-GalNAc biotin

分子量 1916.21
公式 C83H146N14O34S
储存 Store at -20°C
纯度 ≥90% (HPLC)
InChI Key GFCCTIAQGWLOHY-PTYDYDFOSA-N
Smiles O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OCCCCC(NCCCNC(CCOCC(NC(CCNC(CCOCCOCCOCCNC(CCCC[C@@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@@H]5O[C@H](CO)[C@H](O)[C@H](O)[C@H]5NC(C)=O)=O)=O)=O)=O)O[C@@H]1CO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for tri-GalNAc biotin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 95.81 50

制备储备液 for tri-GalNAc biotin

以下数据基于产品分子量 1916.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 1.04 mL 5.22 mL 10.44 mL
2.5 mM 0.21 mL 1.04 mL 2.09 mL
5 mM 0.1 mL 0.52 mL 1.04 mL
25 mM 0.02 mL 0.1 mL 0.21 mL

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产品说明书 for tri-GalNAc biotin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for tri-GalNAc biotin

参考文献是支持产品生物活性的出版物。

Zhou et al (2021) Development of triantennary N-acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent.Sci. 7 499 PMID: 33791431

If you know of a relevant reference for tri-GalNAc biotin, please let us know.

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关键词: tri-GalNAc biotin, tri-GalNAc biotin supplier, Functionalized, Tri-GalNAc, tools, targeted, protein, degradation, liver, building, blocks, components, LYTAC, lysosomal, targeting, chimera, lysosome, biotinylated, biotin, asialoglycoprotein, receptors, ligands, Degraders, Extracellular, proteins, Asialoglycoprotein, receptor, Building, Blocks, 7635, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia