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tri-GalNAc-C5-amine

Cat. No. 7781 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
化学名： N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide
纯度： ≥90% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for tri-GalNAc-C5-amine

tri-GalNAc-C5-amine is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with an alkylC5 linker and an amine group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

技术数据 for tri-GalNAc-C5-amine

分子量 1615.75
公式 C67H118N14O31
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 2098275-86-4
PubChem ID 129115287
InChI Key WGZBAOGYHCXOAV-WUQQNBSDSA-N
Smiles CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O)[C@@H]1OCCOCCOCCOCCN(N=N2)C=C2COCC(COCC3=CN(N=N3)CCOCCOCCOCCO[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)(NC(CCCCCN)=O)COCC5=CN(N=N5)CCOCCOCCOCCO[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)CO)O)O)NC(C)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for tri-GalNAc-C5-amine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 161.57 100

制备储备液 for tri-GalNAc-C5-amine

以下数据基于产品分子量 1615.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.62 mL 3.09 mL 6.19 mL
5 mM 0.12 mL 0.62 mL 1.24 mL
10 mM 0.06 mL 0.31 mL 0.62 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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产品说明书 for tri-GalNAc-C5-amine

分析证书/产品说明书
化学品安全技术说明书

参考文献 for tri-GalNAc-C5-amine

参考文献是支持产品生物活性的出版物。

Sanhueza et al (2017) Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 139 3528 PMID: 28230359

If you know of a relevant reference for tri-GalNAc-C5-amine, please let us know.

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关键词: tri-GalNAc-C5-amine, tri-GalNAc-C5-amine supplier, triGalNAcC5amine, ASGPR, asialoglycoprotein, receptor, ligand, hepatocytes, conjugation, LYTAC, lysosomal, targeting, chimera, alkylc5, amine, degradation, degraders, Building, Blocks, 7781, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia