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tri-GalNAc COOH

Cat. No. 7401 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
化学名： 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
纯度： ≥90% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for tri-GalNAc COOH

Tri-GalNAc COOH is a functionalized asialoglycoprotein receptor ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates an asialoglycoprotein receptor (ASGPR) ligand with PEG linker and carboxylic acid group reactive handle ready for conjugation to a target protein ligand. Upon binding to the ASGPR tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. Tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes.

技术数据 for tri-GalNAc COOH

分子量 1735.93
公式 C75H134N10O35
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 1953146-81-0
InChI Key SPYOMGAJOYWUJU-JNYSMVCCSA-N
Smiles O=C(CCOCCOCCOCCOCCOCCC(O)=O)NC(COCCC(NCCCNC(CCCCOC1O[C@@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCOC2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)COCCC(NCCCNC(CCCCOC3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for tri-GalNAc COOH

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 86.8 50

制备储备液 for tri-GalNAc COOH

以下数据基于产品分子量 1735.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 1.15 mL 5.76 mL 11.52 mL
2.5 mM 0.23 mL 1.15 mL 2.3 mL
5 mM 0.12 mL 0.58 mL 1.15 mL
25 mM 0.02 mL 0.12 mL 0.23 mL

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产品说明书 for tri-GalNAc COOH

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化学品安全技术说明书

参考文献 for tri-GalNAc COOH

参考文献是支持产品生物活性的出版物。

Zhou et al (2021) Development of triantennary N-Acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent. Sci. 7 499 PMID: 33791431

If you know of a relevant reference for tri-GalNAc COOH, please let us know.

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关键词: tri-GalNAc COOH, tri-GalNAc COOH supplier, Functionalized, LYTAC, degraders, PEG, linkers, targeted, protein, degradation, building, blocks, components, lysosomal, targeting, chimera, lysosome, asialoglycoprotein, receptors, ligands, MoDE-As, Molecular, Degraders, Extracellular, proteins, Asialoglycoprotein, receptor, ASG, Building, Blocks, 7401, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia