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tri-GalNAc-PEG3-Azide

Cat. No. 8015 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
纯度： ≥90% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for tri-GalNAc-PEG3-Azide

tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

技术数据 for tri-GalNAc-PEG3-Azide

分子量 1644.83
公式 C70H125N13O31
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 2925590-71-0
InChI Key QNGSUVMZQPQMPB-CNCRQLPOSA-N
Smiles OC[C@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)O[C@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for tri-GalNAc-PEG3-Azide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 5 4

制备储备液 for tri-GalNAc-PEG3-Azide

以下数据基于产品分子量 1644.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.04 mM 15.2 mL 76 mL 151.99 mL
0.2 mM 3.04 mL 15.2 mL 30.4 mL
0.4 mM 1.52 mL 7.6 mL 15.2 mL
2 mM 0.3 mL 1.52 mL 3.04 mL

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产品说明书 for tri-GalNAc-PEG3-Azide

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for tri-GalNAc-PEG3-Azide

参考文献是支持产品生物活性的出版物。

Sanhueza et al (2017) Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 139 3528 PMID: 28230359

If you know of a relevant reference for tri-GalNAc-PEG3-Azide, please let us know.

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关键词: tri-GalNAc-PEG3-Azide, tri-GalNAc-PEG3-Azide supplier, triGalNAcPEG4Azide, ASGPR, asialoglycoprotein, receptor, ligand, hepatocytes, conjugation, LYTAC, lysosomal, targeting, chimera, PEG3, Azide, GalNAc, targeted, protein, degradation, degraders, TPD, building, blocks, Building, Blocks, 8015, Tocris Bioscience

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