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说明： nNOS/iNOS inhibitor
化学名： 1-(2-Trifluoromethylphenyl)imidazole
纯度： ≥99% (HPLC)
生物活性 for TRIM
A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo.
技术数据 for TRIM
| 分子量 | 212.17 |
| 公式 | C10H7F3N2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 25371-96-4 |
| PubChem ID | 1359 |
| InChI Key | WZBWBNCQUTXYEL-UHFFFAOYSA-N |
| Smiles | FC(F)(F)C1=C(C=CC=C1)N1C=CN=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TRIM
参考文献 for TRIM
参考文献是支持产品生物活性的出版物。
Handy et al (1995) The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br.J.Pharmacol. 116 2349 PMID: 8581267
Handy et al (1996) Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 119 423 PMID: 8886430
Tooker et al (2013) Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation. J.Neurosci. 33 19176 PMID: 24305814
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关键词: TRIM, TRIM supplier, nNOS/iNOS, inhibitors, inhibits, Non-Selective, NOS, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Non-selective, 0919, Tocris Bioscience
1 篇 TRIM 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TRIM 的部分引用包括：
Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111 PMID: 9391161
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