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TRO 19622

Cat. No. 2906 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Binds voltage-dependent anion channel (VDAC)
别名： Olesoxime
化学名： Cholest-4-en-3-one oxime
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TRO 19622

TRO 19622 is a neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.

技术数据 for TRO 19622

分子量 399.65
公式 C27H45NO
储存 Desiccate at +4°C
纯度 ≥98% (HPLC)
CAS Number 22033-87-0
PubChem ID 76971721
InChI Key QNTASHOAVRSLMD-GYKMGIIDSA-N
Smiles [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]([H])4[C@@H](CCCC(C)C)C)=NO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TRO 19622

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 19.98 50
ethanol 7.99 20

制备储备液 for TRO 19622

以下数据基于产品分子量 399.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5 mL 25.02 mL 50.04 mL
2.5 mM 1 mL 5 mL 10.01 mL
5 mM 0.5 mL 2.5 mL 5 mL
25 mM 0.1 mL 0.5 mL 1 mL

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产品说明书 for TRO 19622

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TRO 19622

参考文献是支持产品生物活性的出版物。

Bordet et al (2007) Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J.Pharmacol.Exp.Ther. 322 709 PMID: 17496168

If you know of a relevant reference for TRO 19622, please let us know.

按标靶查看相关产品

关键词: TRO 19622, TRO 19622 supplier, Neuroprotective, neuroregenerative, Binds, voltage-dependent, anion, VDAC, Channels, modulators, Other, TRO19622, mitochondrial, pore, MPTP, olesoxime, spinal, muscular, atrophy, SMA, Olesoxime, Channel, Modulators, Miscellaneous, Compounds, 2906, Tocris Bioscience

2 篇 TRO 19622 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TRO 19622 的部分引用包括：

González et al (2016) Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. Front Neurosci 126 1023 PMID: 26878172

Skals et al (2014) Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore. J Biol Chem 289 19098 PMID: 24860098

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