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TRPC6-PAM-C20

Cat. No. 6875 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective positive allosteric modulator (PAM) of TRPC6
化学名： 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TRPC6-PAM-C20

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.

技术数据 for TRPC6-PAM-C20

分子量 363.41
公式 C22H21NO4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 667427-75-0
PubChem ID 1081484
InChI Key SNICUMZYPOCXCO-UHFFFAOYSA-N
Smiles COC1=C(OC)C=C2C(CC(C)(C)N=C2C2=CC3=CC=CC=C3OC2=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TRPC6-PAM-C20

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.34 100
ethanol 7.27 20

制备储备液 for TRPC6-PAM-C20

以下数据基于产品分子量 363.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for TRPC6-PAM-C20

参考文献是支持产品生物活性的出版物。

Häfner et al (2019) Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium 78 26 PMID: 30594060

If you know of a relevant reference for TRPC6-PAM-C20, please let us know.

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关键词: TRPC6-PAM-C20, TRPC6-PAM-C20 supplier, Transient, receptor, potential, canonical, TRPC6, positive, allosteric, modulators, modulates, PAM, platelet, aggregation, TRPC, 6875, Tocris Bioscience

1 篇 TRPC6-PAM-C20 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TRPC6-PAM-C20 的部分引用包括：

Anastasia et al (2022) New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice. Int J Mol Sci 23 PMID: 36362339

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