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说明： Retinoic acid analog; RAR agonist
别名： Ro 13-7410
化学名： 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for TTNPB
TTNPB is an extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).
技术数据 for TTNPB
| 分子量 | 348.48 |
| 公式 | C24H28O2 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 71441-28-6 |
| PubChem ID | 5289501 |
| InChI Key | FOIVPCKZDPCJJY-JQIJEIRASA-N |
| Smiles | C\C(=C/C1=CC=C(C=C1)C(O)=O)C1=CC=C2C(=C1)C(C)(C)CCC2(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TTNPB
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 3.48 | 10 |
制备储备液 for TTNPB
以下数据基于产品分子量 348.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.7 mL | 143.48 mL | 286.96 mL |
| 0.5 mM | 5.74 mL | 28.7 mL | 57.39 mL |
| 1 mM | 2.87 mL | 14.35 mL | 28.7 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
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产品说明书 for TTNPB
参考文献 for TTNPB
参考文献是支持产品生物活性的出版物。
Minucci et al (1996) Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc.Natl.Acad.Sci.U.S.A. 93 1803 PMID: 8700839
Loeliger et al (1980) Arotinoids, a new class of highly active retinoids. Eur.J.Med.Chem.-Chim.Ther. 15 9
Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 651 PMID: 23868920
If you know of a relevant reference for TTNPB, please let us know.
按产品操作查看相关产品
关键词: TTNPB, TTNPB supplier, Retinoic, acid, analogs, agonists, RAR, Receptors, Ro, 13-7410, Acid, Stem, Cell, Reprogramming, 0761, Tocris Bioscience
7 篇 TTNPB 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TTNPB 的部分引用包括：
Tay et al (2010) A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation. Mol Pharmacol 77 218 PMID: 19884280
Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630 PMID: 27600527
Thomas and Henry (2014) Retinoic acid regulation by CYP26 in vertebrate lens regeneration. Br J Pharmacol 386 291 PMID: 24384390
Francipane and Lagasse (2015) The lymph node as a new site for kidney organogenesis. Stem Cells Transl Med 4 295 PMID: 25646529
Cordeiro et al (2019) Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure PMID: 31178221
Wang et al (2017) Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol 9 338 PMID: 28992291
Zhang et al (2015) Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell 17 735 PMID: 26481520
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.