Tubastatin A hydrochloride

Cat. No. 6270 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent HDAC6 inhibitor

化学名： N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Tubastatin A hydrochloride

Tubastatin A hydrochloride is a potent HDAC6 inhibitor (IC₅₀ = 0.015 μM). Exhibits some selectively for HDAC6 over HDAC8 and 1 (IC₅₀ values are 0.854 and 16.4 μM, respectively). Induces elevated levels of α-tubulin and protects against glutathione-induced oxidative stress in primary neuronal cell culture. Reverses the axonal loss in peripheral neurons in a mouse model of Charcot-Marie-Tooth disease.

技术数据 for Tubastatin A hydrochloride

分子量	371.86
公式	C₂₀H₂₁N₃O₂.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1310693-92-5
PubChem ID	57336514
InChI Key	LJTSJTWIMOGKRJ-UHFFFAOYSA-N
Smiles	CN1CCC2=C(C3=CC=CC=C3N2CC4=CC=C(C(NO)=O)C=C4)C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tubastatin A hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	3.72	10 温和加热

制备储备液 for Tubastatin A hydrochloride

以下数据基于产品分子量 371.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	26.89 mL	134.46 mL	268.92 mL
0.5 mM	5.38 mL	26.89 mL	53.78 mL
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL

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产品说明书 for Tubastatin A hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Tubastatin A hydrochloride

参考文献是支持产品生物活性的出版物。

Butler et al (2010) Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A J.Am.Chem.Soc. 132 10842

d'Ydewalle et al (2011) HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nature medicine 7 26 PMID: 21785432

If you know of a relevant reference for Tubastatin A hydrochloride, please let us know.

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关键词: Tubastatin A hydrochloride, Tubastatin A hydrochloride supplier, HDAC6, potent, inhibitors, inhibits, histone, deacetylases, Class, II, HDACs, 6270, Tocris Bioscience

1 篇 Tubastatin A hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tubastatin A hydrochloride 的部分引用包括：

Steven L et al (2022) INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury. Nat Commun 13 6037 PMID: 36229429

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