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Submit ReviewU 18666A
说明： Inhibitor of Hedgehog (Hh) signaling. Also inhibits cholesterol synthesis
化学名： (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
生物活性 for U 18666A
U 18666A is an inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo.
技术数据 for U 18666A
| 分子量 | 424.07 |
| 公式 | C25H41NO2.HCl |
| 储存 | Desiccate at RT |
| CAS Number | 3039-71-2 |
| PubChem ID | 92722 |
| InChI Key | KXNPVXPOPUZYGB-IOVMHBDKSA-N |
| Smiles | [H][C@@]23CC=C1C[C@@H](OCCN(CC)CC)CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for U 18666A
参考文献 for U 18666A
参考文献是支持产品生物活性的出版物。
Cenedella et al (1980) Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Biochem.Pharmacol. 29 2751 PMID: 6159896
Incardona et al (2000) Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev.Biol. 224 440 PMID: 10926779
Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 264 11796 PMID: 2745416
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关键词: U 18666A, U 18666A supplier, inhibitors, hedgehog, Hh, signaling, inhibits, cholesterol, synthesis, Signalling, Hedgehog, U18666A, Signaling, 1638, Tocris Bioscience
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平均评分: 5 (Based on 1 Review.)
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Cholesterol accumulation increased by U18666A treatment.
By
ASHUTOSH SINGHAL on 01/05/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HeLa
I used 2.5-10 ug/ml of U18666A to inhibit the cholesterol efflux in HeLa cells and it worked perfectly as I observed in U18666A treated HeLa cells accumulated cholesterol significantly. I used Filipin staining to image and quantitate the cholesterol levels.
I dissolved the U18666A in water and stored at -20C in aliquots.
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.