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Submit ReviewU 73343
说明： Analog of U 73122 (Cat. No. 1268)
化学名： 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
纯度： ≥98% (HPLC)
生物活性 for U 73343
U 73343 is an analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.
Active Analog also available.
技术数据 for U 73343
| 分子量 | 466.66 |
| 公式 | C29H42N2O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 142878-12-4 |
| PubChem ID | 114825 |
| InChI Key | CJHWFIUASFBCKN-ZRJUGLEFSA-N |
| Smiles | [H][C@]23[C@@]([C@]([H])(CC[C@@H]4NCCCCCCN5C(CCC5=O)=O)[C@]4(C)CC3)([H])CCC1=CC(OC)=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for U 73343
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 4.67 | 10 温和加热 | |
| ethanol | 2.33 | 5 温和加热 |
制备储备液 for U 73343
以下数据基于产品分子量 466.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.43 mL | 107.14 mL | 214.29 mL |
| 0.5 mM | 4.29 mL | 21.43 mL | 42.86 mL |
| 1 mM | 2.14 mL | 10.71 mL | 21.43 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.29 mL |
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产品说明书 for U 73343
参考文献 for U 73343
参考文献是支持产品生物活性的出版物。
Muto et al (1997) The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J.Pharmacol.Exp.Ther. 282 1379 PMID: 9316850
Kataoka et al (2009) Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J.Neurochem. 108 115 PMID: 19014371
Ma et al (2009) Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J.Pharmacol.Exp.Ther. 328 409 PMID: 19023039
Berven and Barritt (1995) Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow. Biochem.Pharmacol. 49 1373 PMID: 7763279
If you know of a relevant reference for U 73343, please let us know.
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关键词: U 73343, U 73343 supplier, U73343, negative, control, analog, U73122, plc, phospholipases, c, Phospholipases, Phospholipase, C, 4133, Tocris Bioscience
20 篇 U 73343 的引用文献
引用文献是使用了 Tocris 产品的出版物。 U 73343 的部分引用包括：
Samir et al (2023) Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses. iScience 26 106707 PMID: 37250336
Lino et al (2020) Novel metabolic role for BDNF in pancreatic β-cell insulin secretion. Nat Commun 11 1950 PMID: 32327658
Atakpa et al (2018) IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes. Cell Rep 25 3180 PMID: 30540949
Babola et al (2020) Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. ELife 9 e52160 PMID: 31913121
Zhen et al (2009) Phosphatidylinositol (4,5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neurons. Mol Pharmacol 76 1349-59 PMID: 19770351
Yoon et al (2015) The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells. Sci Rep 2015 843024 PMID: 26640326
Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS One 10 e0140369 PMID: 26460748
Rioult-Pedotti et al (2015) DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. J Cereb Blood Flow Metab 10 e0124986 PMID: 25938462
Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481
Jeong Hee et al (2017) Dust particles-induced intracellular Ca2+ signaling and reactive oxygen species in lung fibroblast cell line MRC5. Korean J Physiol Pharmacol 21 327-334 PMID: 28461775
Tabatadze et al (2015) Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci 35 11252 PMID: 26269634
Osman et al (2016) Detachment of surface membrane invagination systems by cationic amphiphilic drugs. PLoS One 6 18536 PMID: 26725955
Dhurgham et al (2022) Regulation of Focal Adhesion Dynamics and Cell Migration by PLC/PI3K-Mediated Metabolism of PtdIns (4,5) P2 in a Breast Cancer Cell Line. Rep Biochem Mol Biol 11 270-281 PMID: 36164622
Giovanni et al (2019) Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell 177 1280-1292.e20 PMID: 31031006
Thomas A et al (2019) A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila. Nature 574 559-564 PMID: 31645735
Rajan et al (2017) A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion. Dev Cell 43 83 PMID: 29017032
Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol 111 1008 PMID: 24335212
Ruisanchez et al (2014) Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J 28 880 PMID: 24249637
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Brenner et al (2014) A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain 155 2124 PMID: 25109670
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