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Submit ReviewU 89843A
说明： Positive allosteric modulator of GABAA receptors
别名： PNU 89843
化学名： 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for U 89843A
U 89843A is a positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.
技术数据 for U 89843A
| 分子量 | 321.85 |
| 公式 | C16H23N5.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 157013-85-9 |
| PubChem ID | 56972182 |
| InChI Key | MNKBXPNQWKUSKU-UHFFFAOYSA-N |
| Smiles | CC2=CC1=C(N3CCCC3)N=C(N4CCCC4)N=C1N2C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for U 89843A
参考文献 for U 89843A
参考文献是支持产品生物活性的出版物。
Bundy et al (1995) Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J.Med.Chem. 38 4161 PMID: 7473542
Haesook et al (1995) U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 275 1390 PMID: 8531107
Rohn et al (1996) Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Biochem.Pharmacol. 51 471 PMID: 8619892
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关键词: U 89843A, U 89843A supplier, Positive, allosteric, modulators, GABAA, receptors, Receptors, U89843A, PNU89843, PAM, PNU, 89843, 2734, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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