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Submit ReviewU 93631
说明： GABAA antagonist
化学名： 4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid 1,1-dimethylethyl ester
纯度： ≥99% (HPLC)
生物活性 for U 93631
U 93631 is a GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.
技术数据 for U 93631
| 分子量 | 299.37 |
| 公式 | C17H21N3O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 152273-12-6 |
| PubChem ID | 197626 |
| InChI Key | NXBSEJKZKXIYMD-UHFFFAOYSA-N |
| Smiles | CC(C)(C)OC(=O)C1=C2N(C=N1)C1=CC=CC=C1NC2(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for U 93631
参考文献 for U 93631
参考文献是支持产品生物活性的出版物。
Dillon et al (1993) U-93631 causes rapid decay of γ-aminobutyric acid-induced chloride currents in recombinant rat γ-aminobutyric acid type A receptors. Mol.Pharmacol. 44 860 PMID: 8232235
Dillon et al (1995) [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J.Pharmacol.Exp.Ther. 272 597 PMID: 7531762
Das et al (2003) The GABAA receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors. Neuropharmacology 44 431 PMID: 12646280
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关键词: U 93631, U 93631 supplier, GABAA, receptor, antagonists, Receptors, U93631, 2745, Tocris Bioscience
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