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UB 165 fumarate

Cat. No. 1348 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1348 has been discontinued.

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说明： Subunit selective nAChR agonist
化学名： 2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for UB 165 fumarate

UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.

许可信息

Sold with the permission of the University of Bristol

技术数据 for UB 165 fumarate

分子量 350.8
公式 C13H15ClN2.C4H4O4
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
PubChem ID 71297058
InChI Key DZFRKSLRKAKJIB-WLHGVMLRSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].ClC1=CC=C(C=N1)C1=CCCC2CCC1N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for UB 165 fumarate

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参考文献 for UB 165 fumarate

参考文献是支持产品生物活性的出版物。

Sharples et al (2000) UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of DA release from rat striatal synaptosomes. J.Neurosci. 20 2783 PMID: 10751429

Wright et al (1997) Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett. 7 2867

Cao et al (2005) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]DA release. Neuropharmacology 48 72 PMID: 15617729

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关键词: UB 165 fumarate, UB 165 fumarate supplier, Subunit, selective, nAChR, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, UB165, 200432-86-6, (Other, Subtypes), 1348, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.