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Submit ReviewUBP 301
说明： Kainate antagonist
化学名： (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
纯度： ≥98% (HPLC)
生物活性 for UBP 301
UBP 301 is a potent kainate receptor antagonist (apparent Kd = 5.94 μM). Displays ~ 30-fold selectivity over AMPA receptors.
技术数据 for UBP 301
| 分子量 | 459.2 |
| 公式 | C15H14IN3O6 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 569371-10-4 |
| PubChem ID | 6604913 |
| InChI Key | JHSYCOCOIYSZGI-NSHDSACASA-N |
| Smiles | O=C(C(I)=CN1C[C@H](N)C(O)=O)N(CC2=CC=C(C(O)=O)C=C2)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for UBP 301
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 2.3 | 5 温和加热 |
制备储备液 for UBP 301
以下数据基于产品分子量 459.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 43.55 mL | 217.77 mL | 435.54 mL |
| 0.25 mM | 8.71 mL | 43.55 mL | 87.11 mL |
| 0.5 mM | 4.36 mL | 21.78 mL | 43.55 mL |
| 2.5 mM | 0.87 mL | 4.36 mL | 8.71 mL |
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产品说明书 for UBP 301
参考文献 for UBP 301
参考文献是支持产品生物活性的出版物。
More et al (2003) Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br.J.Pharmacol. 138 1093 PMID: 12684265
If you know of a relevant reference for UBP 301, please let us know.
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关键词: UBP 301, UBP 301 supplier, Kainate, receptor, antagonists, Glutamate, Receptors, iGluR, Ionotropic, UBP301, 1766, Tocris Bioscience
1 篇 UBP 301 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UBP 301 的部分引用包括：
Cassé et al (2012) Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci 32 5186 PMID: 22496564
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