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Submit ReviewUBP1112
Discontinued Product
1369 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Group III mGlu antagonist
化学名： α-Methyl-3-methyl-4-phosphonophenylglycine
纯度： ≥99% (HPLC)
生物活性 for UBP1112
UBP1112 is an a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors).
技术数据 for UBP1112
| 分子量 | 259.2 |
| 公式 | C10H14NO5P |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 339526-74-8 |
| PubChem ID | 5022489 |
| InChI Key | LLEOLNUKLKCAFG-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C(C)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UBP1112
参考文献 for UBP1112
参考文献是支持产品生物活性的出版物。
Conway et al (2001) Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors. Bioorg.Med.Chem.Lett. 11 777 PMID: 11277518
Miller et al (2003) Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. Br.J.Pharmacol. 139 1523 PMID: 12922940
关键词: UBP1112, UBP1112 supplier, Group, III, antagonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGlu4R, mGlu6R, mGlu7R, mGlu8R, Glutamate, Metabotropic, UBP, 1112, (Metabotropic), 1369, Tocris Bioscience
2 篇 UBP1112 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UBP1112 的部分引用包括：
Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591 PMID: 16920620
Govea et al (2012) Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors. J Biol Chem 217 130 PMID: 22609935
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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