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UCPH 101

Cat. No. 3490 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective non-substrate EAAT1 inhibitor
化学名： 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for UCPH 101

UCPH 101 is a selective non-substrate inhibitor of EAAT1 (IC50 values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a patch-clamp electrophysiology assay (at final concentration up to 10 μM).

技术数据 for UCPH 101

分子量 422.48
公式 C27H22N2O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1118460-77-7
PubChem ID 25223366
InChI Key YBMGNDPBARCLFT-UHFFFAOYSA-N
Smiles NC2=C(C#N)C(C3=CC=C(OC)C=C3)C1=C(O2)CC(C4=C(C=CC=C5)C5=CC=C4)CC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UCPH 101

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.56 25

制备储备液 for UCPH 101

以下数据基于产品分子量 422.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 9.47 mL 47.34 mL 94.68 mL
1.25 mM 1.89 mL 9.47 mL 18.94 mL
2.5 mM 0.95 mL 4.73 mL 9.47 mL
12.5 mM 0.19 mL 0.95 mL 1.89 mL

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产品说明书 for UCPH 101

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for UCPH 101

参考文献是支持产品生物活性的出版物。

Jensen et al (2009) Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J.Med.Chem. 52 912 PMID: 19161278

Erichsen et al (2010) Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J.Med.Chem. 53 7180 PMID: 20857912

Bunch et al (2009) Excitatory amino acid transporters as potential drug targets. Exp.Opin.Ther.Targets 13 719

Abrahamsen et al (2013) Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J.Neurosci. 33 1068 PMID: 23325245

If you know of a relevant reference for UCPH 101, please let us know.

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关键词: UCPH 101, UCPH 101 supplier, Selective, non-substrate, EAAT1, inhibitors, inhibits, excitatory, amino, acid, transporters, glutamate, monoamine, neurotransmitter, GLAST, UCPH101, Glutamate, Transporters, 3490, Tocris Bioscience

4 篇 UCPH 101 的引用文献

引用文献是使用了 Tocris 产品的出版物。 UCPH 101 的部分引用包括：

Brancaccio et al (2017) Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron 93 1420 PMID: 28285822

Liang et al (2014) δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Vision Res 171 5417 PMID: 25052197

Tse et al (2014) Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses. PLoS One 103 49 PMID: 25152321

Dumont et al (2014) Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-α in cortical astrocytes from a rat model of amyotrophic lateral sclerosis. Stroke 9 e97649 PMID: 24836816

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