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UH15-38

Cat. No. 8104 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
化学名： 3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 Scientific Data 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for UH15-38

UH15-38 is a potent and selective receptor interacting protein kinase 3 (RIPK3) inhibitor (IC50 = 20 nM). UH15-38 potently and selectively blocks influenza A-induced necroptosis in alveolar epithelial cells in vivo (IC50 = 39.5 nM), and prevents damage from lung inflammation without compromising antiviral adaptive immune responses or impeding viral clearance. Blocks TNFα-induced necroptosis in primary murine embryonic fibroblasts (IC50 = 98 nM) and mouse cell lines in vitro.

Scientific Data

Cell Viability Published vs Bio-Techne batch comparison for UH15-38 View Larger

Published vs Bio-Techne batch comparison for UH15-38. Inhibition of necroptosis by UH15-38 in human FADD-deficient Jurkat cells. Cells were treated with 10 ng/ml of human TNF alpha for 24 hr in the presence of the dose range of the inhibitors. Cell viability was determined using CellTiter-Glo assay (Promega). IC50 for the published molecule was 238.2 nM and 160.2 nM for the Bio-Techne batch. Data kindly provided by A. Degterev’s laboratory, University of Tufts.

许可信息

Sold under license from Tufts University

技术数据 for UH15-38

分子量 514.45
公式 C26H27N5O2.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key HIVPDYQXZCXJQM-UHFFFAOYSA-N
Smiles O=C1C(C2=CC=CC(O)=C2)=CC3=C(N1C)C=C(NC4=CC=CC(N5CCN(CC5)C)=C4)N=C3.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UH15-38

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.44 100
water 51.44 100

制备储备液 for UH15-38

以下数据基于产品分子量 514.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.72 mL 19.44 mL
5 mM 0.39 mL 1.94 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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参考文献 for UH15-38

参考文献是支持产品生物活性的出版物。

Gautam et al (2024) Necroptosis blockade prevents lung injury in severe influenza. Nature PMID: 38600381

If you know of a relevant reference for UH15-38, please let us know.

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关键词: UH15-38, UH15-38 supplier, potent, selective, receptor, interacting, protein, kinase, 3, RIP3K, inhibitors, inhibits, necroptosis, necrosis, RIPK3, in, vivo, influenza, A, virus, IAV, RIP, Kinases, Necroptosis, Influenza, Viruses, 8104, Tocris Bioscience

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