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Submit ReviewUK 14,304 tartrate
说明： α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
化学名： 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate
纯度： ≥99% (HPLC)
生物活性 for UK 14,304 tartrate
UK 14,304 tartrate is a water-soluble form of UK 14,304 (Cat. No. 0425). Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.
技术数据 for UK 14,304 tartrate
| 分子量 | 442.23 |
| 公式 | C11H10BrN5.C4H6O6 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 70359-46-5 |
| PubChem ID | 11236066 |
| InChI Key | QZHBYNSSDLTCRG-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)C(O)C(O)=O.BrC2=C(NC3=NCCN3)C=CC1=NC=CN=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for UK 14,304 tartrate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 22.11 | 50 |
制备储备液 for UK 14,304 tartrate
以下数据基于产品分子量 442.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.52 mL | 22.61 mL | 45.23 mL |
| 2.5 mM | 0.9 mL | 4.52 mL | 9.05 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.9 mL |
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产品说明书 for UK 14,304 tartrate
参考文献 for UK 14,304 tartrate
参考文献是支持产品生物活性的出版物。
Cambridge (1981) UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes. Eur.J.Pharmacol. 72 413 PMID: 6115759
Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634
Macdonald et al (1997) Gene targeting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000
Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591
If you know of a relevant reference for UK 14,304 tartrate, please let us know.
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关键词: UK 14,304 tartrate, UK 14,304 tartrate supplier, Water-soluble, α2-Adrenergic, alpha2-Adrenergic, Receptors, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptor, a2-adrenergic, UK14304, tartrate, Adrenergic, Alpha-2, 2466, Tocris Bioscience
1 篇 UK 14,304 tartrate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UK 14,304 tartrate 的部分引用包括：
Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361
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