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说明： Potent G9a and GLP inhibitor
化学名： 7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
纯度： ≥98% (HPLC)
生物活性 for UNC 0224
UNC 0224 is a potent G9a and GLP inhibitor (IC50 values are 15 and 20 nM in a ThioGlo assay, respectively). Exhibits >1000-fold selectivity for G9a over SET7, SET8 and SET9. UNC 0224 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.
技术数据 for UNC 0224
| 分子量 | 485.67 |
| 公式 | C26H43N7O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1197196-48-7 |
| PubChem ID | 44251522 |
| InChI Key | XIVUGRBSBIXXJE-UHFFFAOYSA-N |
| Smiles | CN(CC4)CCC4NC1=C2C(C=C(OCCCN(C)C)C(OC)=C2)=NC(N3CCCN(C)CC3)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for UNC 0224
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 48.57 | 100 | |
| DMSO | 48.57 | 100 |
制备储备液 for UNC 0224
以下数据基于产品分子量 485.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.3 mL | 20.59 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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产品说明书 for UNC 0224
参考文献 for UNC 0224
参考文献是支持产品生物活性的出版物。
Liu et al (2009) Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J.Med.Chem. 52 7950 PMID: 19891491
Guan et al (2022) Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 325 PMID: 35418683
If you know of a relevant reference for UNC 0224, please let us know.
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关键词: UNC 0224, UNC 0224 supplier, UNC0224, potent, inhibitors, inhibits, histone, lysine, methyltransferases, htmase, G9a, epigenetics, GLP, induced, pluripotent, stem, cells, reprogramming, iPSC, Lysine, Methyltransferases, G9a/GLP, Stem, Cell, Reprogramming, 3861, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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