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Submit ReviewUNC 1215, acid
说明： Functionalized L3MBTL3 ligand for PROTACs
化学名： 4-[[2,5-Bis[[4-(1-pyrrolidinyl)-1-piperidinyl]carbonyl]phenyl]amino]benzoic acid ditrifluoroacetate
纯度： ≥95% (HPLC)
生物活性 for UNC 1215, acid
UNC 1215, acid is a functionalized L3MBTL3 ligand for PROTAC® research and development. L3MBTL3-recruiting PROTACs induce nuclear-specific protein degradation of target proteins, such as FKBP12(F36V) and BRD2. UNC 1215, acid contains a carboxylic acid handle ready for conjugation to a target protein ligand.
Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for UNC 1215, acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for UNC 1215, acid
| 分子量 | 801.78 |
| 公式 | C33H43N5O4.2CF3CO2H |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| InChI Key | FONQYEMRSJVSSN-UHFFFAOYSA-N |
| Smiles | OC(C1=CC=C(NC2=C(C=CC(C(N3CCC(CC3)N4CCCC4)=O)=C2)C(N5CCC(CC5)N6CCCC6)=O)C=C1)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for UNC 1215, acid
参考文献 for UNC 1215, acid
参考文献是支持产品生物活性的出版物。
Nalawansha et al (2022) Hijacking methyl reader proteins for nuclear-specific protein degradation. J.Am.Chem.Soc. 144 5594 PMID: 35311258
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia