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UNC 6852

Cat. No. 7816 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Polycomb repressive complex 2 (PRC2) Degrader (PROTAC®)
化学名： (2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for UNC 6852

UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC®; DC50 = 0.79 μM). It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand. In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC50 = 0.31 μM, Dmax = 94%), enhancer of zeste homolog 2 (EZH2, DC50 = 0.67 μM, Dmax = 96%), and suppressor of zeste homolog 12 (SUZ12, DC50 = 0.59 μM, Dmax = 82%). In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

技术数据 for UNC 6852

分子量 832.98
公式 C43H48N10O6S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2688842-08-0
PubChem ID 146014466
InChI Key PPNNFXIBKLCMTI-WXEAQWFJSA-N
Smiles O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCCNC(C(C=C4)=CC=C4C5=CN=C(N6C5=NN=C6)NCC7=CC=CO7)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UNC 6852

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 83.3 100

制备储备液 for UNC 6852

以下数据基于产品分子量 832.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.2 mL 6 mL 12.01 mL
5 mM 0.24 mL 1.2 mL 2.4 mL
10 mM 0.12 mL 0.6 mL 1.2 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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参考文献 for UNC 6852

参考文献是支持产品生物活性的出版物。

Potjewyd et al (2020) Degradation of polycomb repressive complex 2 with an EED-targeted bivalent chemical degrader. Cell Chem.Biol. 27 47 PMID: 31831267

Raman et al (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Sci.Rep. 11 15238 PMID: 34315984

If you know of a relevant reference for UNC 6852, please let us know.

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关键词: UNC 6852, UNC 6852 supplier, UNC6852, polycomb, repressive, complex, 2, PRC2, degraders, degrades, PROTAC, tissue, factor, pathway, tfpia, EZH2, EED, SUZ12, Polycomb, Repressive, Complex, (PRC), Degraders, 7816, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia