uPSEM 792 hydrochloride

Cat. No. 6865 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Highly potent PSAM⁴-GlyR and PSAM⁴-5-HT₃ chimeric ion channel agonist; brain-penetrant

化学名： 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride

纯度： ≥98% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for uPSEM 792 hydrochloride

uPSEM 792 hydrochloride is an ultrapotent PSEM (uPSEM) agonist for PSAM⁴-GlyR and PSAM⁴-5HT3 (K_i = 0.7 nM for PSAM⁴-GlyR and <10 nM for PSAM⁴-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM⁴-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM⁴-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.

许可信息

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

技术数据 for uPSEM 792 hydrochloride

分子量	277.75
公式	C₁₄H₁₅N₃O.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2341841-08-3
InChI Key	CDHPEJUYEXNGCV-UHFFFAOYSA-N
Smiles	O=C1C=NC2=C(C=C3C(C4CNCC3C4)=C2)N1C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for uPSEM 792 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	27.77	100

制备储备液 for uPSEM 792 hydrochloride

以下数据基于产品分子量 277.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.6 mL	18 mL	36 mL
5 mM	0.72 mL	3.6 mL	7.2 mL
10 mM	0.36 mL	1.8 mL	3.6 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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产品说明书 for uPSEM 792 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for uPSEM 792 hydrochloride

参考文献是支持产品生物活性的出版物。

Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science doi: 10.1126/science PMID: 30872534

If you know of a relevant reference for uPSEM 792 hydrochloride, please let us know.

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关键词: uPSEM 792 hydrochloride, uPSEM 792 hydrochloride supplier, uPSEM792, hydrochloride, ultrapotent, PSEM, uPSEM, agonists, agonsim, PSAM4-GlyR, PSAM4-5HT3, selective, brain, penetrant, chemogenetics, PSEMs, Nicotinic, (a4b2), Receptors, 6865, Tocris Bioscience

3 篇 uPSEM 792 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 uPSEM 792 hydrochloride 的部分引用包括：

Perez-Sanchez et al (2023) A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons Sci.Transl.Med 15 eadh3839 PMID: 37792955

Ji-Hye et al (2023) Neocortical synaptic engrams for remote contextual memories. Nat Neurosci 26 259-273 PMID: 36564546

Manuel et al (2022) Extrinsic control and intrinsic computation in the hippocampal CA1 circuit. Neuron 110 658-673.e5 PMID: 34890566

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