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Urantide

Cat. No. 5296 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5296 has been discontinued.

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说明： Selective and competitive urotensin II receptor antagonist
别名： [Pen5,DTrp7,Orn8]hU-II(4-11)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Urantide

Urantide is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).

技术数据 for Urantide

分子量 1075.26
公式 C51H66N10O12S2
序列 DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7)

储存 Store at -20°C
CAS Number 669089-53-6
PubChem ID 11520939
InChI Key VXLUBANOZQJZFE-QVKHRKAHSA-N
Smiles CC(C)[C@H](NC(=O)[C@@H]1CSSC(C)(C)[C@@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Urantide

参考文献是支持产品生物活性的出版物。

Patacchini et al (2003) Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. Br.J.Pharmacol. 140 1155 PMID: 14645137

Carotenuto et al (2014) Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J.Med.Chem. 57 5965 PMID: 24992374

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关键词: Urantide, Urantide supplier, Selective, competitive, urotensin, II, antagonists, [Pen5,DTrp7,Orn8]hU-II(4-11), Urotensin-II, Receptors, 5296, Tocris Bioscience

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