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Submit ReviewUrapidil hydrochloride
Discontinued Product
1772 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
说明： α1 antagonist; also 5-HT1A receptor agonist
化学名： 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Urapidil hydrochloride
Urapidil hydrochloride is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist (pIC50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.
技术数据 for Urapidil hydrochloride
| 分子量 | 423.94 |
| 公式 | C20H29N5O3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 64887-14-5 |
| PubChem ID | 167980 |
| InChI Key | KTMLZVUAXJERAT-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC=CC=C1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Urapidil hydrochloride
参考文献 for Urapidil hydrochloride
参考文献是支持产品生物活性的出版物。
Gross et al (1987) Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for α1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 336 597 PMID: 2832770
Kolassa et al (1989) Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil. Am.J.Cardiol. 64 7D PMID: 2569265
van Zwieten PA (1989) Pharmacologic profile of urapidil. Am.J.Cardiol. 64 1D PMID: 2569262
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关键词: Urapidil hydrochloride, Urapidil hydrochloride supplier, 5-HT1A, agonists, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, antagonists, Serotonin, Receptors, Adrenergic, Alpha-1, 1772, Tocris Bioscience
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.