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UVI 3003

Cat. No. 3303 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

This product has been withdrawn from sale and is superseded by HX 531 (Cat. No. 3912)
说明： RXR antagonist
化学名： 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for UVI 3003

UVI 3003 is a RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.

技术数据 for UVI 3003

分子量 436.58
公式 C28H36O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 847239-17-2
PubChem ID 44566108
InChI Key APJSHECCIRQQDV-ZRDIBKRKSA-N
Smiles CC1(C)C2=C(C=C(C3=C(O)C=CC(/C=C/C(O)=O)=C3)C(OCCCCC)=C2)C(C)(C)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for UVI 3003

参考文献是支持产品生物活性的出版物。

Le Maire et al (2009) Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO Rep. 10 367 PMID: 19270714

Santin et al (2009) Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. J.Med.Chem. 52 3150 PMID: 19408900

Nahoum et al (2007) Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 104 17323

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关键词: UVI 3003, UVI 3003 supplier, UVI3003, rxr, retinoid, x, receptors, antagonists, Retinoid, X, Receptor, 3303, Tocris Bioscience

4 篇 UVI 3003 的引用文献

引用文献是使用了 Tocris 产品的出版物。 UVI 3003 的部分引用包括：

Porcu et al (2015) Clobetasol and halcin. Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation. PLoS One 10 e0144550 PMID: 26658258

Cambray et al (2012) AVNinduces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors. Nat Commun 3 841 PMID: 22588303

Hebert (2017) Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res 361 101 PMID: 29017757

Marconett et al (2013) Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet 9 e1003513 PMID: 23818859

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.