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V 9302 hydrochloride

Cat. No. 8057 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： ASCT2 (SLC1A5) inhibitor
化学名： (2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid hydrochloride
纯度： ≥97% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for V 9302 hydrochloride

V 9302 hydrochloride is an alanine-serine-cysteine transporter 2 (ASCT2, encoded by gene SLC1A5) inhibitor. It inhibits glutamate uptake (IC50 = 9.6 μM in HEK-293 cells). It reduces cancer cell growth and proliferation, also increases cell death and oxidative stress in vitro and in vivo. V 9302 hydrochloride inhibits mTORC1 activity, mitochondrial respiration, proliferation and migration of vascular smooth muscle cells (VSMCs).

许可信息

Sold under license from Vanderbilt University

技术数据 for V 9302 hydrochloride

分子量 575.15
公式 C34H38N2O4.HCl
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 2416138-42-4
PubChem ID 145710038
InChI Key LUQMUDMPRZSZTJ-YNMZEGNTSA-N
Smiles CC1=CC=CC(COC(C=CC=C2)=C2CN(CC[C@H](N)C(O)=O)CC3=C(C=CC=C3)OCC4=CC(C)=CC=C4)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for V 9302 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.76 50 温和加热
ethanol 28.76 50 温和加热

制备储备液 for V 9302 hydrochloride

以下数据基于产品分子量 575.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.48 mL 17.39 mL 34.77 mL
2.5 mM 0.7 mL 3.48 mL 6.95 mL
5 mM 0.35 mL 1.74 mL 3.48 mL
25 mM 0.07 mL 0.35 mL 0.7 mL

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产品说明书 for V 9302 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for V 9302 hydrochloride

参考文献是支持产品生物活性的出版物。

Schulte et al (2018) Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat.Med. 24 194 PMID: 29334372

Park et al (2021) V-9302 inhibits proliferation and migration of VSMCs, and reduces neointima formation in mice after carotid artery ligation. Biochem.Biophys.Res.Commun. 560 45 PMID: 33965788

Li et al (2022) Inhibitor of glutamine metabolism V9302 promotes ROSinduced autophagic degradation of B7H3 to enhance antitumor immunity. J.Biol.Chem. 298 101753 PMID: 35189139

If you know of a relevant reference for V 9302 hydrochloride, please let us know.

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